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Article

dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants.

Proceedings of the National Academy of Sciences of the United States of America - 12 May 2015

Williams Lindsey N, Marjavaara Lisette, Knowels Gary M, Schultz Eric M, Fox Edward J, Chabes Andrei, Herr Alan J

Abstract excerpt

Mutator phenotypes create genetic diversity that fuels tumor evolution. DNA polymerase (Pol) ε mediates leading strand DNA replication. Proofreading defects in this enzyme drive a number of human malignancies. Here, using budding yeast, we show that mutator variants of Pol ε depend on damage uninducible (Dun)1, an S-phase checkpoint kinase that maintains dNTP levels during a normal cell cycle and up-regulates...

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Identifiers

PMID: 25827226
DOI: 10.1073/pnas.1422948112
PMCID: PMC4434706

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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