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Article

Elevated dNTP levels suppress hyper-recombination in Saccharomyces cerevisiae S-phase checkpoint mutants.

Nucleic acids research - 1 Mar 2010

Fasullo Michael, Tsaponina Olga, Sun Mingzeng, Chabes Andrei

Abstract excerpt

MEC1, the essential yeast homolog of the human ATR/ATM genes, controls the S-phase checkpoint and prevents replication fork collapse at slow zones of DNA replication. The viability of hypomorphic mec1-21 is reduced in the rad52 mutant, defective in homologous recombination, suggesting that replication generates recombinogenic lesions. We previously observed a 6-, 10- and 30-fold higher rate of spontaneous sister...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19965764
DOI: 10.1093/nar/gkp1064
PMCID: PMC2831302

Genes

ATM
ATR

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Elevated dNTP levels suppress hyper-recombination in Saccharomyces cerevisiae S-phase checkpoint mutants.PMID 19965764Read ↗

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