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Beyond proofreading: POLD1 mutations as dynamic orchestrators of genomic instability and immune evasion in cancer

30 Jun 2025

Abstract excerpt

DNA polymerase delta (Pol δ) is a cornerstone of genomic stability, orchestrating DNA replication and repair through its catalytic subunit, POLD1. This subunit's 3'-5' exonuclease domain proofreads replication errors, ensuring fidelity. However, POLD1 mutations-particularly in this domain-disrupt this function, triggering genomic instability and a hypermutated state in cancers. This review delves into the...

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PMID: 40661943
DOI: 10.3389/fimmu.2025.1600233

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