Article
Molecular basis of the essential s phase function of the rad53 checkpoint kinase.
Molecular and cellular biology - 1 Aug 2013
Hoch Nicolas C, Chen Eric S-W, Buckland Robert, Wang Shun-Chung, Fazio Alessandro, Hammet Andrew, Pellicioli Achille, Chabes Andrei, Tsai Ming-Daw, Heierhorst Jörg
Abstract excerpt
The essential yeast kinases Mec1 and Rad53, or human ATR and Chk1, are crucial for checkpoint responses to exogenous genotoxic agents, but why they are also required for DNA replication in unperturbed cells remains poorly understood. Here we report that even in the absence of DNA-damaging agents, the rad53-4AQ mutant, lacking the N-terminal Mec1 phosphorylation site cluster, is synthetic lethal with a deletion of...
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