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Amino- and Carboxyl-Terminal CCR5 Mutations in Brazilian HIV-1-Infected Women and Homology Model of p.L55Q CCR5 Mutant.

AIDS research and human retroviruses - 1 Jul 2015

Costa Giselle Calasans de Souza, Nunes Marcio Roberto T, Jesus Jaqueline Goes, Novaes Thiago, Cardoso Jedson Ferreira, Sousa Júnior Edivaldo Costa, Santos Edson de Souza, Galvão-Castro Bernardo, Zanette Dalila Luciola, Gonçalves Marilda de Souza, Alcantara Luiz Carlos Junior

Abstract excerpt

Genetic factors from an HIV-1 host can affect the rate of progression to AIDS and HIV infection. To investigate the frequency of mutations in the CCR5 gene, HIV-1 samples from infected women and uninfected individuals were selected for sequencing of the CCR5 gene regions encoding the N- and C-terminal protein domains. Physicochemical CCR5 modeling and potential protein domain analysis were performed in order to...

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PMID: 25825809
DOI: 10.1089/AID.2014.0140

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CCR5

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