Article
New genetic variants in the CCR5 gene and the distribution of known polymorphisms in Omani population.
International journal of immunogenetics - 1 Feb 2014
Al-Mahruqi S H, Zadjali F, Koh C Y, Balkhair A, Said E A, Al-Balushi M S, Hasson S S, Al-Jabri A A
Abstract excerpt
C-C motif chemokine receptor-5 (CCR5) is a pro-inflammatory receptor that binds to chemokines and facilitates the entry of the R5 strain of HIV-1. A number of polymorphisms were identified within the promoter and coding regions of the CCR5 gene, some of which have been found to affect the protein expression and thus receptor function. Although several CCR5 polymorphisms were shown to vary widely in their...
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