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Article

Structural insight into a novel human CCR5-V130I variant associated with resistance to HIV-1 infection.

Journal of biomolecular structure & dynamics - 1 Jan 2014

Stambouli Nejla, Wei Ning-Ning, Jlizi Asma, Aissa Samah, Abdelmalek Rim, Kilani Baderredine, Slim Amine, Tiouiri Ben Aissa Hanen, Dridi Mahdi, Hamza Adel, Ben Ammar Elgaied Amel

Abstract excerpt

We report the identification of a novel CC chemokine receptor 5 (CCR5) variant that seems associated with resistance to HIV-1 infection. The V130I mutation of the CCR5 receptor is located in the intracellular loop ICL2 known as DRY box and described in the literature as a nonsynonymous mutation present in nonhuman primates group. Extensive molecular modeling and dynamics simulations were performed to elucidate...

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Identifiers

PMID: 23869485
DOI: 10.1080/07391102.2013.819297

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CCR5

Variants

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