Article
An efficiently cleaved HIV-1 clade C Env selectively binds to neutralizing antibodies.
PloS one - 1 Jan 2015
Boliar Saikat, Das Supratik, Bansal Manish, Shukla Brihaspati N, Patil Shilpa, Shrivastava Tripti, Samal Sweety, Goswami Sandeep, King C Richter, Bhattacharya Jayanta, Chakrabarti Bimal K
Abstract excerpt
An ideal HIV-1 Env immunogen is expected to mimic the native trimeric conformation for inducing broadly neutralizing antibody responses. The native conformation is dependent on efficient cleavage of HIV-1 Env. The clade B isolate, JRFL Env is efficiently cleaved when expressed on the cell surface. Here, for the first time, we report the identification of a native clade C Env, 4-2.J41 that is naturally and...
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