Article

Functional and Highly Crosslinkable HIV-1 Envelope Glycoproteins Enriched in a Pretriggered Conformation

2021-09-30

Abstract excerpt

<h4>ABSTRACT</h4> Binding to the receptor, CD4, drives the pretriggered, “closed” (State-1) conformation of the human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer into more “open” conformations (States 2 and 3). Broadly neutralizing antibodies, which are elicited inefficiently, mostly recognize the State-1 Env conformation, whereas the more commonly elicited poorly neutralizing antibodies rec...

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Literature Corpus work: 95abfc2c-1031-51d8-acb0-9b1a66f75f6c
DOI: 10.1101/2021.09.27.462085

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