Article
Glycine Substitution at Helix-to-Coil Transitions Facilitates the Structural Determination of a Stabilized Subtype C HIV Envelope Glycoprotein.
Immunity - 16 May 2017
Guenaga Javier, Garces Fernando, de Val Natalia, Stanfield Robyn L, Dubrovskaya Viktoriya, Higgins Brett, Carrette Barbara, Ward Andrew B, Wilson Ian A, Wyatt Richard T
Abstract excerpt
Advances in HIV-1 envelope glycoprotein (Env) design generate native-like trimers and high-resolution clade A, B, and G structures and elicit neutralizing antibodies. However, a high-resolution clade C structure is critical, as this subtype accounts for the majority of HIV infections worldwide, but well-ordered clade C Env trimers are more challenging to produce due to their instability. Based on targeted glycine...
Topics
- Amino Acid Substitution
- Antibodies, Neutralizing
- Binding Sites
- Genotype
- Glycine
- Glycosylation
- HIV Antibodies
- HIV Envelope Protein gp120
- HIV Envelope Protein gp41
- HIV-1