Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glycine Substitution at Helix-to-Coil Transitions Facilitates the Structural Determination of a Stabilized Subtype C HIV Envelope Glycoprotein.

Immunity - 16 May 2017

Guenaga Javier, Garces Fernando, de Val Natalia, Stanfield Robyn L, Dubrovskaya Viktoriya, Higgins Brett, Carrette Barbara, Ward Andrew B, Wilson Ian A, Wyatt Richard T

Abstract excerpt

Advances in HIV-1 envelope glycoprotein (Env) design generate native-like trimers and high-resolution clade A, B, and G structures and elicit neutralizing antibodies. However, a high-resolution clade C structure is critical, as this subtype accounts for the majority of HIV infections worldwide, but well-ordered clade C Env trimers are more challenging to produce due to their instability. Based on targeted glycine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Neutralizing
Share to env Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HIV Antibodies

Share to HIV Envelope Protein gp120

Share to HIV Envelope Protein gp41

Share to Protein Conformation, alpha-Helical

Share to Proteolysis

Share to Solubility

Source

Open in PubMed Open full text

Identifiers

PMID: 28514686
DOI: 10.1016/j.immuni.2017.04.014
PMCID: PMC5439057

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glycine Substitution at Helix-to-Coil Transitions Facilitates the Structural Determination of a Stabilized Subtype C HIV Envelope Glycoprotein.PMID 28514686Read ↗

Structure-Guided Redesign Increases the Propensity of HIV Env To Generate Highly Stable Soluble TrimersSemantic proximity Read ↗

Structure-guided design of native-like HIV Env Single Chain Trimers for enhanced stability, immunogenicity, and versatile vaccine deliverySemantic proximity Read ↗

A Universal Approach to Optimize the Folding and Stability of Prefusion-Closed HIV-1 Envelope TrimersSemantic proximity Read ↗

Stabilization of the V2 loop improves the presentation of V2 loop–associated broadly neutralizing antibody epitopes on HIV-1 envelope trimersSemantic proximity Read ↗

Cleavage-Independent HIV-1 Env Trimers Engineered as Soluble Native Spike Mimetics for Vaccine DesignSemantic proximity Read ↗

Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogensSemantic proximity Read ↗

Changes at V2 apex of HIV-1 Clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodiesSemantic proximity Read ↗

The Design and Immunogenicity of an HIV-1 Clade C Pediatric Envelope Glycoprotein Stabilized by Multiple PlatformsSemantic proximity Read ↗

Improving the Expression and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers by Targeted Sequence Changes.Semantic proximity Read ↗

Contemporary HIV-1 consensus Env with AI-assisted redesigned hypervariable loops promote antibody bindingSemantic proximity Read ↗

Structural insights into key sites of vulnerability on <scp>HIV</scp>‐1 Env and influenza <scp>HA</scp>Semantic proximity Read ↗

Structure and immune recognition of trimeric pre-fusion HIV-1 Env.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.