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Article

A Native-Like SOSIP.664 Trimer Based on an HIV-1 Subtype B <i>env</i> Gene

15 Jan 2015

Abstract excerpt

UNLABELLED: Recombinant trimeric mimics of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) spike should expose as many epitopes as possible for broadly neutralizing antibodies (bNAbs) but few, if any, for nonneutralizing antibodies (non-NAbs). Soluble, cleaved SOSIP.664 gp140 trimers based on the subtype A strain BG505 approach this ideal and are therefore plausible vaccine candidates....

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Identifiers

PMID: 25589637
DOI: 10.1128/jvi.03473-14

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