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Article

Improving the Expression and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers by Targeted Sequence Changes.

Journal of virology - 15 Jun 2017

Ringe Rajesh P, Ozorowski Gabriel, Yasmeen Anila, Cupo Albert, Cruz Portillo Victor M, Pugach Pavel, Golabek Michael, Rantalainen Kimmo, Holden Lauren G, Cottrell Christopher A, Wilson Ian A, Sanders Rogier W, Ward Andrew B, Klasse P J, Moore John P

Abstract excerpt

Soluble, recombinant native-like envelope glycoprotein (Env) trimers of various human immunodeficiency virus type 1 (HIV-1) genotypes are being developed for structural studies and as vaccine candidates aimed at the induction of broadly neutralizing antibodies (bNAbs). The prototypic design is designated SOSIP.664, but many HIV-1 env genes do not yield fully native-like trimers efficiently. One such env gene is...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to env Gene Products, Human Immunodeficiency Virus

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Source

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Identifiers

PMID: 28381572
DOI: 10.1128/JVI.00264-17
PMCID: PMC5446630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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