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Contemporary HIV-1 consensus Env with AI-assisted redesigned hypervariable loops promote antibody binding

9 May 2024

Abstract excerpt

An effective HIV-1 vaccine must elicit broadly neutralizing antibodies (bnAbs) against highly diverse Envelope glycoproteins (Env). Since Env with the longest hypervariable (HV) loops is more resistant to the cognate bnAbs than Env with shorter HV loops, we redesigned hypervariable loops for updated Env consensus sequences of subtypes B and C and CRF01_AE. Using modeling with AlphaFold2, we reduced the length of...

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PMID: 38724518
DOI: 10.1038/s41467-024-48139-x

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