Structure and immune recognition of trimeric pre-fusion HIV-1 Env.

doi:10.1038/nature13808

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Article

Structure and immune recognition of trimeric pre-fusion HIV-1 Env.

Nature - 23 Oct 2014

Pancera Marie, Zhou Tongqing, Druz Aliaksandr, Georgiev Ivelin S, Soto Cinque, Gorman Jason, Huang Jinghe, Acharya Priyamvada, Chuang Gwo-Yu, Ofek Gilad, Stewart-Jones Guillaume B E, Stuckey Jonathan, Bailer Robert T, Joyce M Gordon, Louder Mark K, Tumba Nancy, Yang Yongping, Zhang Baoshan, Cohen Myron S, Haynes Barton F, Mascola John R, Morris Lynn, Munro James B, Blanchard Scott C, Mothes Walther, Connors Mark, Kwong Peter D

Abstract excerpt

The human immunodeficiency virus type 1 (HIV-1) envelope (Env) spike, comprising three gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by rearranging from a mature unliganded state, through receptor-bound intermediates, to a post-fusion state. As the sole viral antigen on the HIV-1 virion surface, Env is both the target of neutralizing antibodies and a focus of vaccine...

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PMID: 25296255
DOI: 10.1038/nature13808
PMCID: PMC4348022

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