Article
HIV-1 Envelope Glycoproteins Proteolytic Cleavage Protects Infected Cells from ADCC Mediated by Plasma from Infected Individuals.
Viruses - 6 Nov 2021
Prévost Jérémie, Medjahed Halima, Vézina Dani, Chen Hung-Ching, Hahn Beatrice H, Smith Amos B, Finzi Andrés
Abstract excerpt
The HIV-1 envelope glycoprotein (Env) is synthesized in the endoplasmic reticulum as a trimeric gp160 precursor, which requires proteolytic cleavage by a cellular furin protease to mediate virus-cell fusion. Env is conformationally flexible but controls its transition from the unbound "closed" conformation (State 1) to downstream CD4-bound conformations (States 2/3), which are required for fusion. In particular,...
Topics
- Amino Acid Motifs
- Antibody-Dependent Cell Cytotoxicity
- CD4-Positive T-Lymphocytes
- Cell Membrane
- HIV Antibodies
- HIV Envelope Protein gp160
- HIV Infections
- HIV-1
- Humans
- Mutation
- Protein Conformation
- Proteolysis
- Virion