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Article

Structure-guided design of native-like HIV Env Single Chain Trimers for enhanced stability, immunogenicity, and versatile vaccine delivery

2025-10-26

Abstract excerpt

<h4>ABSTRACT</h4> Stabilizing the HIV envelope (Env) trimer in its native prefusion conformation is key to eliciting broadly neutralizing antibodies (bnAbs). We present a generalizable single-chain trimer-(SCT) design platform that enables the production of stable, native-like Env trimers across diverse HIV strains. Using a structure-guided approach, we developed CAP256.SU-SCT9, based on a CAP256.SU Env shown to...

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Literature Corpus work
3a25f44c-cbcb-5bdc-9dd6-0332ad95041c
DOI
10.1101/2025.10.25.684215
Open publication

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Structure-guided design of native-like HIV Env Single Chain Trimers for enhanced stability, immunogenicity, and versatile vaccine deliveryDOI 10.1101/2025.10.25.684215
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