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Article

A comparison of 454 sequencing and clonal sequencing for the characterization of hepatitis C virus NS3 variants.

Journal of virological methods - 1 Jul 2015

Ho Cynthia K Y, Welkers Matthijs R A, Thomas Xiomara V, Sullivan James C, Kieffer Tara L, Reesink Henk W, Rebers Sjoerd P H, de Jong Menno D, Schinkel Janke, Molenkamp Richard

Abstract excerpt

We compared 454 amplicon sequencing with clonal sequencing for the characterization of intra-host hepatitis C virus (HCV) NS3 variants. Clonal and 454 sequences were obtained from 12 patients enrolled in a clinical phase I study for telaprevir, an NS3-4a protease inhibitor. Thirty-nine datasets w...

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Source

Identifiers

PMID: 25818622
DOI: 10.1016/j.jviromet.2015.03.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25818622-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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