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Article

Deep sequencing analysis of HCV NS3 resistance-associated variants and mutation linkage in liver transplant recipients.

PloS one - 1 Jan 2013

Kirst Mariana E, Li Eric C, Wang Cindy X, Dong Hui-Jia, Liu Chen, Fried Michael W, Nelson David R, Wang Gary P

Abstract excerpt

Viral variants with decreased susceptibility to HCV protease inhibitors (PIs) occur naturally and preexist at low levels within HCV populations. In patients failing PI monotherapy, single and double mutants conferring intermediate to high-level resistance to PIs have been selected in vivo. The abundance, temporal dynamics and linkage of naturally occurring resistance-associated variants (RAVs), however, have not...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23922778
DOI: 10.1371/journal.pone.0069698
PMCID: PMC3726766

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