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Article

Ultradeep pyrosequencing of NS3 to predict response to triple therapy with protease inhibitors in previously treated chronic hepatitis C patients.

Journal of clinical microbiology - 1 Feb 2015

Larrat Sylvie, Kulkarni Om, Claude Jean-Baptiste, Beugnot Réjane, Blum Michaël G B, Fusillier Katia, Lupo Julien, Tremeaux Pauline, Plages Agnès, Marlu Alice, Duborjal Hervé, Signori-Schmuck Anne, Francois Olivier, Zarski Jean-Pierre, Morand Patrice, Leroy Vincent

Abstract excerpt

Despite the gain in sustained virological responses (SVR) provided by protease inhibitors (PIs), failures still occur. The aim of this study was to determine if a baseline analysis of the NS3 region using ultradeep pyrosequencing (UDPS) can help to predict an SVR. Serum samples from 40 patients with previously nonresponding genotype 1 chronic hepatitis C who were retreated with triple therapy, including a PI,...

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Share to Antiviral Agents
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Therapy, Combination

Share to Hepatitis C, Chronic

Share to Mutation, Missense

Share to Protease Inhibitors

Share to Salvage Therapy

Share to Viral Nonstructural Proteins

Source

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Identifiers

PMID: 25411182
DOI: 10.1128/JCM.02547-14
PMCID: PMC4298514

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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