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Article

Deep sequencing is an appropriate tool for the selection of unique Hepatitis C virus (HCV) variants after single genomic amplification.

PloS one - 1 Jan 2017

Guinoiseau Thibault, Moreau Alain, Hohnadel Guillaume, Ngo-Giang-Huong Nicole, Brulard Celine, Vourc'h Patrick, Goudeau Alain, Gaudy-Graffin Catherine

Abstract excerpt

Hepatitis C virus (HCV) evolves rapidly in a single host and circulates as a quasispecies wich is a complex mixture of genetically distinct virus's but closely related namely variants. To identify intra-individual diversity and investigate their functional properties in vitro, it is necessary to define their quasispecies composition and isolate the HCV variants. This is possible using single genome amplification...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28362878
DOI: 10.1371/journal.pone.0174852
PMCID: PMC5376297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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