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Article

Hepatitis C Virus (HCV) NS3 sequence diversity and antiviral resistance-associated variant frequency in HCV/HIV coinfection.

Antimicrobial agents and chemotherapy - 1 Oct 2014

Jabara Cassandra B, Hu Fengyu, Mollan Katie R, Williford Sara E, Menezes Prema, Yang Yan, Eron Joseph J, Fried Michael W, Hudgens Michael G, Jones Corbin D, Swanstrom Ronald, Lemon Stanley M

Abstract excerpt

HIV coinfection accelerates disease progression in chronic hepatitis C and reduces sustained antiviral responses (SVR) to interferon-based therapy. New direct-acting antivirals (DAAs) promise higher SVR rates, but the selection of preexisting resistance-associated variants (RAVs) may lead to virologic breakthrough or relapse. Thus, pretreatment frequencies of RAVs are likely determinants of treatment outcome but...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25092699
DOI: 10.1128/AAC.03466-14
PMCID: PMC4187920

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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