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Article

Deep sequencing of hepatitis C virus hypervariable region 1 reveals no correlation between genetic heterogeneity and antiviral treatment outcome.

BMC infectious diseases - 13 Jul 2014

Cortés Kamila Caraballo, Zagordi Osvaldo, Perlejewski Karol, Laskus Tomasz, Maroszek Krzysztof, Bukowska-Ośko Iwona, Pawełczyk Agnieszka, Płoski Rafał, Berak Hanna, Horban Andrzej, Radkowski Marek

Abstract excerpt

BACKGROUND: Hypervariable region 1 (HVR1) contained within envelope protein 2 (E2) gene is the most variable part of HCV genome and its translation product is a major target for the host immune response. Variability within HVR1 may facilitate evasion of the immune response and could affect treatment outcome. The aim of the study was to analyze the impact of HVR1 heterogeneity employing sensitive ultra-deep...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25016390
DOI: 10.1186/1471-2334-14-389
PMCID: PMC4226954

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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