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Article

Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains.

Neurobiology of aging - 1 May 2015

Zhu Caihong, Herrmann Uli S, Li Bei, Abakumova Irina, Moos Rita, Schwarz Petra, Rushing Elisabeth J, Colonna Marco, Aguzzi Adriano

Abstract excerpt

Dysfunctional variants of the innate immune cell surface receptor TREM2 (triggering receptor expressed on myeloid cells-2) were identified as major genetic risk factors for Alzheimer's disease and other neurodegenerative conditions. Here we assessed a possible involvement of TREM2 in prion diseas...

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Source

Identifiers

PMID: 25816748
DOI: 10.1016/j.neurobiolaging.2015.02.019

Genes

TREM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25816748-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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