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Article

A motif from Lys216 to Lys222 in human BUB3 protein is a nuclear localization signal and critical for BUB3 function in mitotic checkpoint.

The Journal of biological chemistry - 1 May 2015

Zhu Songcheng, Jing Ruiqi, Yang Yiwei, Huang Yitong, Wang Xin, Leng Ye, Xi Jiajie, Wang Guiying, Jia Wenwen, Kang Jiuhong

Abstract excerpt

Human BUB3 is a key mitotic checkpoint factor that recognizes centromeric components and recruits other mitotic checkpoint molecules to the unattached kinetochore. The key amino acid residues responsible for its localization are not yet defined. In this study, we identified a motif from Lys(216) to Lys(222) in BUB3 as its nuclear localization signal. A BUB3 mutant with deletion of this motif (Del216-222) was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25814666
DOI: 10.1074/jbc.M114.598029
PMCID: PMC4416835

Genes

BUB3
BUB1
KNL1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A motif from Lys216 to Lys222 in human BUB3 protein is a nuclear localization signal and critical for BUB3 function in mitotic checkpoint.PMID 25814666Read ↗

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