Article
The crystal structure of the N-terminal region of BUB1 provides insight into the mechanism of BUB1 recruitment to kinetochores.
Structure (London, England : 1993) - 14 Jan 2009
Bolanos-Garcia Victor M, Kiyomitsu Tomomi, D'Arcy Sheena, Chirgadze Dimitri Y, Grossmann J Günter, Matak-Vinkovic Dijana, Venkitaraman Ashok R, Yanagida Mitsuhiro, Robinson Carol V, Blundell Tom L
Abstract excerpt
The interaction of the central mitotic checkpoint component BUB1 with the mitotic kinetochore protein Blinkin is required for the kinetochore localization and function of BUB1 in the mitotic spindle assembly checkpoint, the regulatory mechanism of the cell cycle that ensures the even distribution of chromosomes during the transition from metaphase to anaphase. Here, we report the 1.74 angstroms resolution crystal...
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