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Article

Association of DNA repair gene variants with colorectal cancer: risk, toxicity, and survival.

BMC cancer - 12 May 2020

Salimzadeh Hamideh, Lindskog Elinor Bexe, Gustavsson Bengt, Wettergren Yvonne, Ljungman David

Abstract excerpt

BACKGROUND: Single nucleotide polymorphisms (SNPs) in DNA repair genes have a potential clinical value in predicting treatment outcomes. In the current study, we examined the association of SNPs in the genes XRCC1-rs25487, ERCC1-rs11615, ERCC2-rs238406, and ERCC2-rs13181 with colorectal cancer (CRC) risk, relapse-free survival (RFS), overall survival (OS), and toxicity during chemotherapy. METHODS: SNPs were...

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Adult

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Aged

Aged, 80 and over

Antineoplastic Combined Chemotherapy Protocols

Chemotherapy, Adjuvant

Colorectal Neoplasms

DNA-Binding Proteins

Drug-Related Side Effects and Adverse Reactions

Endonucleases

Female

Follow-Up Studies

Genotype

Humans

Male

Middle Aged

Neoplasm Recurrence, Local

Polymorphism, Single Nucleotide

Prognosis

Source

Open in PubMed Open full text

Identifiers

PMID: 32397974
DOI: 10.1186/s12885-020-06924-z
PMCID: PMC7216326

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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