Article
Genetic variation in radiation and platinum pathways predicts severe acute radiation toxicity in patients with esophageal adenocarcinoma treated with cisplatin-based preoperative radiochemotherapy: results from the Eastern Cooperative Oncology Group.
Cancer chemotherapy and pharmacology - 1 Oct 2011
Yoon H H, Catalano P, Gibson M K, Skaar T C, Philips S, Montgomery E A, Hafez M J, Powell M, Liu G, Forastiere A A, Benson A B, Kleinberg L R, Murphy K M
Abstract excerpt
PURPOSE: Germline genetic variations may partly explain the clinical observation that normal tissue tolerance to radiochemotherapy varies by individual. Our objective was to evaluate the association between single-nucleotide polymorphisms (SNPs) in radiation/platinum pathways and serious treatment-related toxicity in subjects with esophageal adenocarcinoma who received cisplatin-based preoperative...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.