Article
Polymorphisms in DNA repair genes XRCC1, XRCC3 and XPD, and colorectal cancer risk: a case-control study in an Indian population.
Journal of cancer research and clinical oncology - 1 Oct 2010
Wang Jingwen, Zhao Yang, Jiang Jing, Gajalakshmi Vendhan, Kuriki Kiyonori, Nakamura Seiichi, Akasaka Susumu, Ishikawa Hideki, Suzuki Sadao, Nagaya Teruo, Tokudome Shinkan
Abstract excerpt
PURPOSE: Genetic polymorphisms in DNA repair genes may influence variations in individual DNA repair capacity, which could be associated with the development of cancer. We detected the distributions of three single-nucleotide polymorphisms (XRCC1 Arg399Gln, XRCC3 Thr241Met and XPD Lys751Gln) in DNA repair genes, and assessed the associations of these genetic polymorphisms with colon and rectal cancer...
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