Association between single nucleotide polymorphisms in the XRCC1 and RAD51 genes and clinical radiosensitivity in head and neck cancer.

doi:10.1016/j.radonc.2011.05.062

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Article

Association between single nucleotide polymorphisms in the XRCC1 and RAD51 genes and clinical radiosensitivity in head and neck cancer.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 Jun 2011

Pratesi Nicola, Mangoni Monica, Mancini Irene, Paiar Fabiola, Simi Lisa, Livi Lorenzo, Cassani Sara, Buglione Michela, Grisanti Salvatore, Almici Camillo, Polli Caterina, Saieva Calogero, Magrini Stefano Maria, Biti Giampaolo, Pazzagli Mario, Orlando Claudio

Abstract excerpt

PURPOSE: Individual variability in radiosensitivity is large in cancer patients. Single nucleotide polymorphisms (SNPs) in genes involved in DNA repair and in protection against reactive oxygen species (ROS) could be responsible for such cases of radiosensitivity. We investigated the association between the occurrence of acute reactions in 101 patients with squamous cell carcinoma of the head and neck (SCCHN)...

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Identifiers

PMID: 21704413
DOI: 10.1016/j.radonc.2011.05.062

Genes

RAD51
XRCC1
GSTP1
XRCC3

Variants

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