Article
High-depth sequencing of over 750 genes supports linear progression of primary tumors and metastases in most patients with liver-limited metastatic colorectal cancer.
Genome biology - 12 Feb 2015
Tan Iain Beehuat, Malik Simeen, Ramnarayanan Kalpana, McPherson John R, Ho Dan Liang, Suzuki Yuka, Ng Sarah Boonhsui, Yan Su, Lim Kiat Hon, Koh Dennis, Hoe Chew Min, Chan Chung Yip, Ten Rachel, Goh Brian Kp, Chung Alexander Yf, Tan Joanna, Chan Cheryl Xueli, Tay Su Ting, Alexander Lezhava, Nagarajan Niranjan, Hillmer Axel M, Tang Choon Leong, Chua Clarinda, Teh Bin Tean, Rozen Steve, Tan Patrick
Abstract excerpt
BACKGROUND: Colorectal cancer with metastases limited to the liver (liver-limited mCRC) is a distinct clinical subset characterized by possible cure with surgery. We performed high-depth sequencing of over 750 cancer-associated genes and copy number profiling in matched primary, metastasis and normal tissues to characterize genomic progression in 18 patients with liver-limited mCRC. RESULTS: High depth Illumina...
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