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Comparative sequencing analysis reveals high genomic concordance between matched primary and metastatic colorectal cancer lesions

27 Aug 2014

Abstract excerpt

BACKGROUND: Colorectal cancer is the second leading cause of cancer death in the United States, with over 50,000 deaths estimated in 2014. Molecular profiling for somatic mutations that predict absence of response to anti-EGFR therapy has become standard practice in the treatment of metastatic colorectal cancer; however, the quantity and type of tissue available for testing is frequently limited. Further, the...

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PMID: 25164765
DOI: 10.1186/s13059-014-0454-7

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