Article
A system for detecting high impact-low frequency mutations in primary tumors and metastases.
Oncogene - 11 Jan 2018
Anjanappa M, Hao Y, Simpson E R, Bhat-Nakshatri P, Nelson J B, Tersey S A, Mirmira R G, Cohen-Gadol A A, Saadatzadeh M R, Li L, Fang F, Nephew K P, Miller K D, Liu Y, Nakshatri H
Abstract excerpt
Tumor complexity and intratumor heterogeneity contribute to subclonal diversity. Despite advances in next-generation sequencing (NGS) and bioinformatics, detecting rare mutations in primary tumors and metastases contributing to subclonal diversity is a challenge for precision genomics. Here, in order to identify rare mutations, we adapted a recently described epithelial reprograming assay for short-term...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.