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Article

Single-cell exome sequencing reveals multiple subclones in metastatic colorectal carcinoma.

Genome medicine - 10 Sept 2021

Tang Jie, Tu Kailing, Lu Keying, Zhang Jiaxun, Luo Kai, Jin Haoxuan, Wang Lei, Yang Lie, Xiao Weiran, Zhang Qilin, Liu Xiaoling, Ge Xin Yi, Li Guibo, Zhou Zongguang, Xie Dan

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) is a major cancer type whose mechanism of metastasis remains elusive. METHODS: In this study, we characterised the evolutionary pattern of metastatic CRC (mCRC) by analysing bulk and single-cell exome sequencing data of primary and metastatic tumours from 7 CRC patients with liver metastases. Here, 7 CRC patients were analysed by bulk whole-exome sequencing (WES); 4 of these...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34507604
DOI: 10.1186/s13073-021-00962-3
PMCID: PMC8434739

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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