Article
Defective tumor necrosis factor release from Crohn's disease macrophages in response to Toll-like receptor activation: relationship to phenotype and genome-wide association susceptibility loci.
Inflammatory bowel diseases - 1 Nov 2012
Sewell Gavin W, Rahman Farooq Z, Levine Adam P, Jostins Luke, Smith Philip J, Walker Ann P, Bloom Stuart L, Segal Anthony W, Smith Andrew M
Abstract excerpt
BACKGROUND: Recent work provides evidence of a failure of acute inflammation in Crohn's disease (CD), and suggests that the primary defect operates at the level of the macrophage and cytokine release. Here we extend the characterization of the innate immune defect in CD by investigating the macrophage response to Toll-like receptor (TLR) agonists and assess potential links between genome-wide association study...
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