Article
Comparative genomics of Crohn's disease-associated adherent-invasive Escherichia coli.
Gut - 1 Aug 2017
O'Brien Claire L, Bringer Marie-Agnès, Holt Kathryn E, Gordon David M, Dubois Anaëlle L, Barnich Nicolas, Darfeuille-Michaud Arlette, Pavli Paul
Abstract excerpt
OBJECTIVE: Adherent-invasive Escherichia coli (AIEC) are a leading candidate bacterial trigger for Crohn's disease (CD). The AIEC pathovar is defined by in vitro cell-line assays examining specific bacteria/cell interactions. No molecular marker exists for their identification. Our aim was to identify a molecular property common to the AIEC phenotype. DESIGN: 41 B2 phylogroup E. coli strains were isolated from 36...
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