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Article

Crohn's disease-associated adherent-invasive <i>E.âcoli</i> are selectively favoured by impaired autophagy to replicate intracellularly

11 Sept 2009

Abstract excerpt

Ileal lesions in Crohn's disease (CD) patients are colonized by pathogenic adherent-invasive Escherichia coli (AIEC) able to invade and to replicate within intestinal epithelial cells. Recent genome-wide association studies have highlighted the autophagy pathway as being associated with CD risk. In the present study we investigated whether defects in autophagy enhance replication of commensal and pathogenic...

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PMID: 19747213
DOI: 10.1111/j.1462-5822.2009.01381.x

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