LTA4H genotype is associated with susceptibility to bacterial meningitis but is not a critical determinant of outcome.

doi:10.1371/journal.pone.0118789

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Article

LTA4H genotype is associated with susceptibility to bacterial meningitis but is not a critical determinant of outcome.

PloS one - 1 Jan 2015

Dunstan Sarah J, Tram Trinh Thi Bich, Thwaites Guy E, Chau Tran Thi Hong, Phu Nguyen Hoan, Hien Tran Tinh, Farrar Jeremy J, Wolbers Marcel, Mai Nguyen Thi Hoang

Abstract excerpt

Adjunctive dexamethasone saves lives in the treatment of tuberculous meningitis but this response is influenced by the patient's LTA4H genotype. Despite less certain benefit, adjunctive dexamethasone is also frequently used in the treatment of pyogenic bacterial meningitis, but the influence of LTA4H genotype on outcomes has not been previously investigated. We genotyped the LTA4H promoter region SNP (rs17525495)...

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PMID: 25799317
DOI: 10.1371/journal.pone.0118789
PMCID: PMC4370666

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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