Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Leukotriene A4 Hydrolase Genotype and HIV Infection Influence Intracerebral Inflammation and Survival From Tuberculous Meningitis.

The Journal of infectious diseases - 1 Apr 2017

Thuong Nguyen T T, Heemskerk Dorothee, Tram Trinh T B, Thao Le T P, Ramakrishnan Lalita, Ha Vu T N, Bang Nguyen D, Chau Tran T H, Lan Nguyen H, Caws Maxine, Dunstan Sarah J, Chau Nguyen V V, Wolbers Marcel, Mai Nguyen T H, Thwaites Guy E

Abstract excerpt

Background: Tuberculous meningitis (TBM) is the most devastating form of tuberculosis, yet very little is known about the pathophysiology. We hypothesized that the genotype of leukotriene A4 hydrolase (encoded by LTA4H), which determines inflammatory eicosanoid expression, influences intracerebral inflammation, and predicts survival from TBM. Methods: We characterized the pretreatment clinical and intracerebral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiretroviral Therapy, Highly Active
Share to Antitubercular Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epoxide Hydrolases

Share to Kaplan-Meier Estimate

Share to Leukocytes

Share to Multivariate Analysis

Share to Mycobacterium tuberculosis

Share to Proportional Hazards Models

Source

Open in PubMed Open full text

Identifiers

PMID: 28419368
DOI: 10.1093/infdis/jix050
PMCID: PMC5426373

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Leukotriene A4 Hydrolase Genotype and HIV Infection Influence Intracerebral Inflammation and Survival From Tuberculous Meningitis.PMID 28419368Read ↗

Elevated cerebrospinal fluid cytokine levels in tuberculous meningitis predict survival in response to dexamethasoneSemantic proximity Read ↗

Clinical Parameters, Routine Inflammatory Markers, and LTA4H Genotype as Predictors of Mortality Among 608 Patients With Tuberculous Meningitis in Indonesia.Semantic proximity Read ↗

Elevated cerebrospinal fluid cytokine levels in tuberculous meningitis predict survival in response to dexamethasone.Semantic proximity Read ↗

A Bayesian analysis of the association between <i>Leukotriene A4 Hydrolase</i> genotype and survival probability of tuberculous meningitis patients treated with adjunctive dexamethasoneSemantic proximity Read ↗

Statistical analysis plan for the LAST ACT clinical trial; a Leukotriene A4 hydrolase Stratified non-inferiority Trial of Adjunctive Corticosteroids for HIV-negative adults with Tuberculous meningitisSemantic proximity Read ↗

LTA4H genotype is associated with susceptibility to bacterial meningitis but is not a critical determinant of outcome.Semantic proximity Read ↗

Genotype-stratified adjunctive dexamethasone for tuberculous meningitis in HIV-negative adults: a randomized controlled phase 3 trial.Semantic proximity Read ↗

Evaluating the Impact of LTA4H Genotype and Immune Status on Survival From Tuberculous Meningitis.Semantic proximity Read ↗

Do Intracerebral Cytokine Responses Explain the Harmful Effects of Dexamethasone in Human Immunodeficiency Virus-associated Cryptococcal Meningitis?Semantic proximity Read ↗

Immune reconstitution inflammatory syndrome in non-HIV cryptococcal meningitis: Cross-talk between pathogen and host.Semantic proximity Read ↗

Adjunctive dexamethasone for the treatment of HIV-uninfected adults with tuberculous meningitis stratified by Leukotriene A4 hydrolase genotype (LAST ACT): Study protocol for a randomised double blind placebo controlled non-inferiority trialSemantic proximity Read ↗

A Bayesian analysis of the association between Leukotriene A4 Hydrolase genotype and survival in tuberculous meningitis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.