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Article

Do Intracerebral Cytokine Responses Explain the Harmful Effects of Dexamethasone in Human Immunodeficiency Virus-associated Cryptococcal Meningitis?

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 24 Apr 2019

Beardsley Justin, Hoang Nhat L T, Kibengo Freddie M, Tung Nguyen L N, Binh Tran Q, Hung Le Q, Chierakul Wirongrong, Thwaites Guy E, Chau Nguyen V V, Nguyen Thuong T T, Geskus Ronald B, Day Jeremy N

Abstract excerpt

BACKGROUND: The CryptoDex trial showed that dexamethasone caused poorer clinical outcomes and slowed fungal clearance in human immunodeficiency virus-associated cryptococcal meningitis. We analyzed cerebrospinal fluid (CSF) cytokine concentrations from participants over the first week of treatment to investigate mechanisms of harm and test 2 hypotheses: (1) dexamethasone reduced proinflammatory cytokine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30169607
DOI: 10.1093/cid/ciy725
PMCID: PMC6481995

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TNF

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