Article
A Bayesian analysis of the association between Leukotriene A4 Hydrolase genotype and survival in tuberculous meningitis.
eLife - 8 Jan 2021
Whitworth Laura, Coxon Jacob, van Laarhoven Arjan, Thuong Nguyen Thuy Thuong, Dian Sofiati, Alisjahbana Bachti, Ganiem Ahmad Rizal, van Crevel Reinout, Thwaites Guy E, Troll Mark, Edelstein Paul H, Sewell Roger, Ramakrishnan Lalita
Abstract excerpt
Tuberculous meningitis has high mortality, linked to excessive inflammation. However, adjunctive anti-inflammatory corticosteroids reduce mortality by only 30%, suggesting that inflammatory pathophysiology causes only a subset of deaths. In Vietnam, the survival benefit of anti-inflammatory corticosteroids was most pronounced in patients with a C/T promoter variant in the leukotriene A4 hydrolase (LTA4H) gene...
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