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Article

Genotype-stratified adjunctive dexamethasone for tuberculous meningitis in HIV-negative adults: a randomized controlled phase 3 trial.

Nature medicine - 1 Mar 2026

Donovan Joseph, Duc Bang Nguyen, Dong Huu Khanh Trinh, Ho Dang Trung Nghia, Nguyen Thi Anh Thu, Nguyen Thi Thu Hiep, Lam Hong Bao Ngoc, Phung Vo Khac Nguyen, Nguyen Truc Thanh, Nguyen Ho Hong Hanh, Pham Kieu Nguyet Oanh, Do Dang Anh Thu, Nguyen Thi Mai Trang, Dang Thi Minh Ha, Nguyen Huu Lan, Nguyen Van Vinh Chau, Hoang Thanh Hai, Tran Dinh Dinh, Phung Khanh Lam, Ramakrishnan Lalita, Le Thanh Hoang Nhat, Nguyen Thuy Thuong Thuong, Wolbers Marcel, Kestelyn Evelyne, Geskus Ronald B, Nguyen Hoan Phu, Thwaites Guy E

Abstract excerpt

Adjunctive corticosteroids such as dexamethasone are recommended in tuberculous meningitis treatment, despite modest and heterogeneous survival benefit. Leukotriene A4 hydrolase (LTA4H) genotypes associate with distinct intracerebral inflammatory phenotypes and may determine corticosteroid response in tuberculous meningitis, with benefit observed in hyperinflammatory TT genotype but uncertain benefit in lower...

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Identifiers

PMID: 41540106
DOI: 10.1038/s41591-025-04138-z
PMCID: PMC13004695

Genes

LTA4H

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Genotype-stratified adjunctive dexamethasone for tuberculous meningitis in HIV-negative adults: a randomized controlled phase 3 trial.PMID 41540106Read ↗

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