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Article

Elevated cerebrospinal fluid cytokine levels in tuberculous meningitis predict survival in response to dexamethasone.

Proceedings of the National Academy of Sciences of the United States of America - 9 Mar 2021

Whitworth Laura J, Troll Rajan, Pagán Antonio J, Roca Francisco J, Edelstein Paul H, Troll Mark, Tobin David M, Phu Nguyen Hoan, Bang Nguyen Duc, Thwaites Guy E, Thuong Nguyen Thuy Thuong, Sewell Roger F, Ramakrishnan Lalita

Abstract excerpt

Adjunctive treatment with antiinflammatory corticosteroids like dexamethasone increases survival in tuberculosis meningitis. Dexamethasone responsiveness associates with a C/T variant in Leukotriene A4 Hydrolase (LTA4H), which regulates expression of the proinflammatory mediator leukotriene B4 (LTB4). TT homozygotes, with increased expression of LTA4H, have the highest survival when treated with dexamethasone and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33658385
DOI: 10.1073/pnas.2024852118
PMCID: PMC7958233

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