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Article

Excitotoxic insult results in a long-lasting activation of CaMKIIα and mitochondrial damage in living hippocampal neurons.

PloS one - 1 Jan 2015

Otmakhov Nikolai, Gorbacheva Elena V, Regmi Shaurav, Yasuda Ryohei, Hudmon Andy, Lisman John

Abstract excerpt

Over-activation of excitatory NMDA receptors and the resulting Ca2+ overload is the main cause of neuronal toxicity during stroke. CaMKII becomes misregulated during such events. Biochemical studies show either a dramatic loss of CaMKII activity or its persistent autonomous activation after stroke, with both of these processes being implicated in cell toxicity. To complement the biochemical data, we monitored...

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PMID: 25793533
DOI: 10.1371/journal.pone.0120881
PMCID: PMC4368532

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