Article
Involvement of calmodulin in neuronal cell death.
Brain research - 14 Apr 2006
Shirasaki Yasufumi, Kanazawa Yoshito, Morishima Yoshiyuki, Makino Mitsuhiro
Abstract excerpt
A large body of evidence indicates that disturbances of Ca(2+) homeostasis may be a causative factor in the neurotoxicity following cerebral ischemia. However, the mechanisms by which Ca(2+) overload leads to neuronal cell death have not been fully elucidated. Calmodulin, a major intracellular Ca(2+)-binding protein found mainly in the central nervous system, mediates many physiological functions in response to...
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