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Article

Degradation of CaMKII is stimulated by its active conformation.

The Journal of biological chemistry - 1 Oct 2025

Quasney Christina, Griffith Leslie C

Abstract excerpt

Maintaining synaptic protein levels that support both functional stability and plasticity is crucial for the proper function of the nervous system. Calcium/calmodulin-dependent protein kinase II (CaMKII) plays a pivotal role in synaptic signaling, with its synaptic levels regulated by both activity-dependent translocation from the cytosol and local translation. However, the mechanisms governing the removal of...

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Identifiers

PMID: 40818612
DOI: 10.1016/j.jbc.2025.110601
PMCID: PMC12624777

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