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Article

Mitochondrial DNA mutations affect calcium handling in differentiated neurons.

Brain : a journal of neurology - 1 Mar 2010

Trevelyan Andrew J, Kirby Denise M, Smulders-Srinivasan Tora K, Nooteboom Marco, Acin-Perez Rebeca, Enriquez José Antonio, Whittington Miles A, Lightowlers Robert N, Turnbull Doug M

Abstract excerpt

Mutations in the mitochondrial genome are associated with a wide range of neurological symptoms, but many aspects of the basic neuronal pathology are not understood. One candidate mechanism, given the well-established role of mitochondria in calcium buffering, is a deficit in neuronal calcium hom...

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Identifiers

PMID: 20207702
DOI: 10.1093/brain/awq023
PMCID: PMC2842518

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20207702-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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