Article
Low blood folates in NTD pregnancies are only partly explained by thermolabile 5,10-methylenetetrahydrofolate reductase: low folate status alone may be the critical factor.
American journal of medical genetics - 30 Jun 1998
Molloy A M, Mills J L, Kirke P N, Ramsbottom D, McPartlin J M, Burke H, Conley M, Whitehead A S, Weir D G, Scott J M
Abstract excerpt
Thermolabile 5,10-methylenetetrahydrofolate reductase (MTHFR) is the first folate-related variant to be associated with an increased risk of neural tube defects (NTDs). The variant causes high plasma homocysteine levels and reduced red cell folate (RCF) levels, both of which have also been linked...
Topics
- 5,10-Methylenetetrahydrofolate Reductase (FADH2)
- Case-Control Studies
- Cysteine
- Female
- Folic Acid
- Genotype
- Humans
- Methylenetetrahydrofolate Reductase (NADPH2)
- Neural Tube Defects
- Oxidoreductases
- Pregnancy
- Pregnancy Complications
- Threonine