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Article

Folate levels and N(5),N(10)-methylenetetrahydrofolate reductase genotype (MTHFR) in mothers of offspring with neural tube defects: a case-control study.

Archives of medical research - 1 Jan 2000

Martínez de Villarreal L E, Delgado-Enciso I, Valdéz-Leal R, Ortíz-López R, Rojas-Martínez A, Limón-Benavides C, Sánchez-Peña M A, Ancer-Rodríguez J, Barrera-Saldaña H A, Villarreal-Pérez J Z

Abstract excerpt

BACKGROUND: Neural tube defects (NTDs) have been associated with biochemical factors involved in the conversion of homocysteine to methionine as folate deficiency and the mutation 677T in the N(5),N(10)-methylenetetrahydrofolate reductase gene (MTHFR). METHODS: A case-control study was performed to detect this mutation in 38 unrelated women with NTD deceased products and 31 mothers without antecedents of NTD...

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Source

Identifiers

PMID: 11440783
DOI: 10.1016/s0188-4409(01)00292-2

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Folate levels and N(5),N(10)-methylenetetrahydrofolate reductase genotype (MTHFR) in mothers of offspring with neural tube defects: a case-control study.PMID 11440783Read ↗

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