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Article

Variants in host viral replication cycle genes are associated with heterosexual HIV-1 acquisition in Africans.

Journal of acquired immune deficiency syndromes (1999) - 1 Jun 2014

Bigham Abigail W, Mackelprang Romel D, Celum Connie, De Bruyn Guy, Beima-Sofie Kristin, John-Stewart Grace, Ronald Allan, Mugo Nelly R, Buckingham Kati, Bamshad Michael J, Mullins James I, McElrath M J, Lingappa Jairam R

Abstract excerpt

OBJECTIVE: We evaluated genetic variants in 51 candidate genes encoding proteins that interact with HIV-1 during the virus life cycle for association with HIV-1 outcomes in an African cohort. METHODS: Using a nested case-control study within a cohort of heterosexual HIV-1-serodiscordant couples, we genotyped 475 haplotype-tagging single-nucleotide polymorphisms (tagSNPs) and 18 SNPs previously associated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24463784
DOI: 10.1097/QAI.0000000000000113
PMCID: PMC4025588

Genes

CCR5
FUT2
MBL2
PPIA
SMARCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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