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Article

Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling.

Bioorganic & medicinal chemistry - 15 Nov 2012

Wang Jiangbo, Mook Robert A, Lu Jiuyi, Gooden David M, Ribeiro Anthony, Guo Anchen, Barak Larry S, Lyerly H Kim, Chen Wei

Abstract excerpt

The Hedgehog signaling pathway plays an essential role in embryo development and adult tissue homeostasis, in regulating stem cells and is abnormally activated in many cancers. Given the importance of this signaling pathway, we developed a novel and versatile high-throughput, cell-based screening platform using confocal imaging, based on the role of β-arrestin in Hedgehog signal transduction, that can identify...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23063522
DOI: 10.1016/j.bmc.2012.09.030
PMCID: PMC3501270

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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